Abstract
The article presents and discusses the problems of implementing national projects aimed at strengthening and preserving public health, improving healthcare activities on the example of the South Siberian macroregion, including the Novosibirsk, Omsk, Tomsk, Kemerovo regions, Altai Krai and the Altai Republic; emphasis is placed on a comparative analysis of the state and dynamics of the main health indicators, indicators of the development of health systems of the subjects of the macroregion; open data of state statistics, information posted on the websites of the authorities of the subjects of the Russian Federation, ratings of territories, author's assessments of ongoing processes; conclusions and recommendations are made.