Abstract
The spatial nature of innovation activity in the modern USA is determined by the urban orientation of the territorial forms of this activity and depends on the complex impact of both regional factors and effects arising in transregional systems, which are defined by the author as innovative systems of agglomerations in United States and are the central object of this study. Comprehensive comparative analysis of territorial differences in terms of indicators and integrated index of regional development of the United States innovation systems and innovation systems of agglomerations within the country’s metropolitan statistical areas in 2001—2020 revealed the spatial heterogeneity of centre-peripheral innovation. The impact of the factors that caused the innovative development of the territories of the United States, based on the universal influence of three effects of urban-oriented placement of elements and processes of innovation activity, the most important of which are, respectively, innovative companies and the associated flow of knowledge and technologies, is empirically confirmed.