Abstract
The subject of the study is the attractiveness of the development of high-tech industries in the United States in the space of urban areas that economically and statistically correspond to the mega-regions of the country. Modeling the relationship between the field of settlement / field of economic activity and the attractiveness of industry within the framework of the Industry 4.0 concept implemented in the United States in the 2010s allows us to obtain combined empirical results calculated on average over two ten-year periods of time of the current century. The latter fully or partially confirm the urban-oriented nature of the interdependence of innovative/knowledge-intensive areas of production and the urbanized settlement system, which changes under the influence of system-cyclic factors, both in time and in space.