Accelerated development of Siberia is possible only on the basis of using its resource potential, which is represented by huge reserves of minerals. This means that the development of the mineral resource complex will remain a priority for a long period. In this regard, the question arises, to what extent do industries with raw material specialization ensure sustainable regional development? To assess the sustainability of the regional economic system, indicators are proposed that reflect economic growth, social development, and environmental condition. As the study showed, the development of industries for the extraction of minerals contributes to significant economic growth in resource regions, thanks to which they provide the main volume of income for the consolidated budget, an increase in the gross regional product, and the attraction of investments. An analysis of social development indicators did not reveal any advantages in the standard of living of the population in resource regions compared to non-resource regions. Environmental indicators indicate an extremely unfavorable situation in the field of environmental safety, which has developed in regions of raw material specialization. The results obtained can be used in regulating the processes of managing the mineral resource complex at both the state and regional levels.